Harry Millspaugh had five goals and three assists, and Zane Moorhead also scored five times as the third-seeded Flyers (10-3) downed the sixth-seeded Lakers (6-7) in a Class C quarterfinal at Portland.
Oliver Burdick chipped in with three goals and two assists, Sam Whipple scored two goals, and Mitchell Adams had a goal and seven assists. Miles Lipton and Liam Feeney also scored for Waynflete, which led 11-2 at halftime.
The Flyers will visit second-seeded North Yarmouth Academy in the semifinals.
Peter Vigna and Nate Bragdon-Clements scored for Lake Region.