Fifth-seeded Falmouth (9-5) scored the first five goals and never looked back en route to a Class A North semifinal victory at No. 1 Windham.
The Yachtsmen stretched their lead to 9-1 at halftime and 13-2 after three quarters.
Wyatt Kerr had four goals and three assists, Peter Alexander added three goals, and Iyendae St. Louis and Reilly Tucker each recorded two goals and three assists for Falmouth, which will play at No. 2 Portland (12-1) in the regional final at 5 p.m. Wednesday.
Windham (11-2) got two goals from Travis Brown and 16 saves from Ben Elliott.